Identification of Divergent Protein Domains by Combining HMM-HMM Comparisons and Co-Occurrence Detection
نویسندگان
چکیده
منابع مشابه
Identification of Divergent Protein Domains by Combining HMM-HMM Comparisons and Co-Occurrence Detection
Identification of protein domains is a key step for understanding protein function. Hidden Markov Models (HMMs) have proved to be a powerful tool for this task. The Pfam database notably provides a large collection of HMMs which are widely used for the annotation of proteins in sequenced organisms. This is done via sequence/HMM comparisons. However, this approach may lack sensitivity when searc...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2014
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0095275